Fructose intolerance: Diet and inheritance

Fructose intolerance: diet and inheritance.

Hereditary Fructose Intolerance (HFI; first recognized as a clinical entity by Chambers & Pratt, (1956)) provides a vivid example of interactions between changing dietary factors and inheritance in the development of human disease. Although the cultivation of sugar has its roots in antiquity, its importance as a foodstuff has developed only over the last 300 or so years with the rise of sugar-c...

Fructose Intolerance.

Hereditary fructose intolerance.

Hereditary fructose intolerance (HFI, OMIM 22960), caused by catalytic deficiency of aldolase B (fructose-1,6-bisphosphate aldolase, EC 4.1.2.13), is a recessively inherited condition in which affected homozygotes develop hypoglycaemic and severe abdominal symptoms after taking foods containing fructose and cognate sugars. Continued ingestion of noxious sugars leads to hepatic and renal injury ...

Fructose Intolerance and Hypoglucosemia in the Newborn Fructose Tolerance

The normal newborn infant has inadequate homeostatic mechanisms for stabilizing the concentration of glucose in the blood (1, 2). Recent studies of carbohydrate metabolism in this age group have indicated a diminished responsiveness to small doses (30 jug per kg body weight) of exogenous glucagon (3, 4) and a slow rate of disappearance from the blood of either glucose or galactose administered ...

Manifestation of hereditary fructose intolerance.

Death from P. falciparum infection in subjects who live in areas of stable malaria is usually due either to cerebral involvement or to the consequences of anaemia (Edington and Gilles, 1969). Almost all the data on increased resistance against malaria have been obtained in A/S heterozygotes, and there is no a priori reason to expect that they should apply to S/S homozygotes. In addition, one ca...